Zak S. is attempting something very cool over at his blog (warning for occasional NSFWish content):
Playing D&D With Porn Stars: Open Call: Gigacrawler: "I'm thinking we could make a whole RPG via Gygaxian Democracy... Here's how it'll work: I provide the basic setting idea and the basic mech..."
The concept of the entire universe/multiverse as dungeon has a very Planescape feel to it- I like it!